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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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The link between vascular dysfunction, bladder ischemia, and aging bladder dysfunction.

Karl-Erik Andersson1, Donna B Boedtkjer2, Axel Forman3

  • 1Institute of Clinical Medicine, Department of Obstetrics and Gynecology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, DK 8200 Aarhus N, Denmark.

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Summary
This summary is machine-generated.

Pelvic arterial insufficiency contributes to bladder dysfunction in aging. Several drugs, including tadalafil and silodosin, show promise in protecting bladder function and structure from ischemia-related damage in animal models.

Keywords:
LUTSagingbladder blood flowbladder dysfunctionischemiapharmacological treatment

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Area of Science:

  • Urology
  • Gerontology
  • Vascular Biology

Background:

  • Aging impairs blood vessel function, potentially affecting bladder vasculature.
  • Pelvic arterial insufficiency is linked to bladder dysfunctions like detrusor overactivity (DO) and overactive bladder syndrome.
  • Chronic ischemia can lead to bladder underactivity and morphological changes, necessitating treatments for symptoms and disease progression.

Conclusions:

  • Pelvic arterial insufficiency is a significant factor in age-related bladder dysfunction.
  • Pharmacological agents targeting vascular and oxidative stress pathways may prevent or mitigate functional and morphological bladder damage.
  • Results from animal models suggest translational value for clinical studies aimed at preventing the progression of ischemia-related bladder changes.