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Filamentous Influenza Viruses

Matthew D Badham1, Jeremy S Rossman1

  • 1School of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK.

Current Clinical Microbiology Reports
|January 3, 2017
PubMed

Insights

Influenza A virus can be spherical or filamentous. Researchers are exploring viral and host factors influencing filamentous influenza virus formation and its role in infection spread.

Area of Science:

  • Virology
  • Microbiology
  • Pathogen Research

Background:

  • Influenza A virus (IAV) is a significant global pathogen.
  • IAV exhibits pleomorphism, forming spherical and filamentous virions.
  • The formation and function of filamentous IAV remain poorly understood.

Purpose of the Study:

  • To review current knowledge on IAV assembly and budding.
  • To identify viral and host factors determining IAV morphology.
  • To discuss the potential role of filamentous morphology in viral spread.

Main Methods:

  • Literature review and synthesis of existing research.
  • Analysis of viral and host factors involved in IAV morphogenesis.
  • Discussion of recent findings on filamentous IAV in vivo.

Main Results:

  • IAV assembly and budding involve complex viral and host interactions.
  • Specific factors influencing the determination of viral morphology are highlighted.
  • Emerging evidence suggests filamentous IAV may aid in viral dissemination.

Conclusions:

  • Understanding IAV morphology is crucial for comprehending its replication cycle.
  • Filamentous IAV morphology may play a role in facilitating in vivo spread.
  • Further research is needed to elucidate the biological significance of filamentous IAV.
Keywords:
AssemblyBuddingFilamentsInfluenza virusMorphology

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