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Targeting Cancer using Polymeric Nanoparticle mediated Combination Chemotherapy.
Aniket Gad1, Janel Kydd1, Brandon Piel2
1Biomedical Engineering and Biotechnology Program, University of Massachusetts, Lowell, USA.
International Journal of Nanomedicine and Nanosurgery
|January 3, 2017
Summary
Polymeric nanoparticles offer a promising solution for cancer treatment by improving chemotherapy delivery. This approach enhances drug efficacy and overcomes resistance, minimizing side effects for better patient outcomes.
Area of Science:
- Nanotechnology
- Oncology
- Materials Science
Background:
- Conventional chemotherapy faces limitations including severe side effects and acquired drug resistance in cancer cells.
- Nanotechnology offers innovative drug delivery systems to overcome these challenges.
- Nanoparticles can improve drug bioavailability, reduce clearance, and enhance efficacy through the enhanced permeability and retention effect.
Purpose of the Study:
- To review recent advancements in using polymeric nanoparticles for combination chemotherapy delivery.
- To explore modifications in nanoparticle delivery parameters that enhance therapeutic efficacy.
- To validate the potential of nanoparticle-based combination therapy for cancer treatment.
Main Methods:
- Utilizing biocompatible and biodegradable polymers for nanoparticle formulation.
- Optimizing nanoparticle properties (size, surface charge, stealth modifications) for improved drug delivery.
- Investigating surface modifications with targeting moieties for enhanced cellular uptake.
- Reviewing in vitro and animal model studies on combination chemotherapy efficacy.
Main Results:
- Polymeric nanoparticles demonstrate potential as effective carriers for chemotherapeutic agents.
- Sustained and controlled drug release from nanoparticles enhances bioavailability and therapeutic effect.
- Combination therapy delivered via nanoparticles shows synergistic cytotoxicity and potential to overcome multidrug resistance.
- Targeted nanoparticle delivery increases drug accumulation in cancer cells, improving efficacy.
Conclusions:
- Polymeric nanoparticles represent a significant advancement in targeted cancer therapy.
- Optimized nanoparticle design and combination chemotherapy can effectively combat drug resistance and improve treatment outcomes.
- This approach holds substantial promise for developing more effective anticancer treatments with reduced collateral damage.
Keywords:
BiocompatibilityBiodegradabilityBiopolymersControlled releaseDrug deliveryEnhanced permeability and retentionMulti-drug resistanceNanomedicineOncologyReceptor mediated endocytosisMore Related Videos
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