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Cardiovascular comorbidities in acromegaly: an update on their diagnosis and management

Ana M Ramos-Leví1, Mónica Marazuela2

  • 1Department of Endocrinology, Hospital Universitario La Princesa, Instituto de Investigación Princesa, Universidad Autónoma, Madrid, Spain.

Endocrine
|January 3, 2017
PubMed

Insights

Acromegaly frequently causes cardiovascular comorbidities like hypertension and cardiomyopathy, increasing mortality risk. Early screening and treatment are crucial for managing these heart conditions in acromegaly patients.

Area of Science:

  • Endocrinology
  • Cardiology
  • Internal Medicine

Background:

  • Cardiovascular comorbidities are highly prevalent in acromegaly patients.
  • These conditions significantly increase morbidity and all-cause mortality.
  • Common findings include hypertension, cardiomyopathy, arrhythmias, and coronary artery disease.

Purpose of the Study:

  • To review prevalent cardiovascular comorbidities in acromegaly.
  • To discuss their underlying pathophysiology.
  • To provide recommendations for diagnosis, management, and treatment.

Main Methods:

  • Literature review of cardiovascular complications in acromegaly.
  • Discussion of physiopathological factors including growth hormone/insulin-like growth factor 1 excess.
  • Analysis of diagnostic techniques and treatment effects.

Main Results:

  • Cardiovascular comorbidities are frequent and multifactorial in acromegaly.
  • Uncontrolled hormone excess, age, and disease duration are key influences.
  • Prompt diagnosis and management can mitigate cardiac abnormalities.

Conclusions:

  • Cardiovascular health is a critical concern in acromegaly management.
  • A systematic approach to screening and treatment is recommended.
  • Further understanding of diagnostic tools and therapeutic impacts is needed.

Keywords:
acromegalic cardiomyopathyacromegalyacromegaly cardiovascular comorbiditieshypertensionpegvisomantradiotherapysomatostatin analogsvalve disease

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