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Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

60
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
60
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

114
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
114
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

145
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
145
Drug Delivery: Overview01:16

Drug Delivery: Overview

1.1K
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
1.1K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

921
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
921
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

114
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
114

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Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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Clinical experience with drug delivery systems as tools to decrease the toxicity of anticancer chemotherapeutic

Raul C Maranhão1,2, Carolina G Vital1,2, Thauany M Tavoni1,2

  • 1a Heart Institute of the Medical School Hospital , University of São Paulo , São Paulo , Brazil.

Expert Opinion on Drug Delivery
|January 3, 2017
PubMed
Summary
This summary is machine-generated.

Targeted drug delivery systems significantly reduce chemotherapy toxicity, expanding treatment options for more cancer patients. Lipid core nanoparticles show particular promise in concentrating drugs at tumor sites.

Keywords:
Cancer treatmentLDL receptors and cancerchemotherapy toxicitydrug targetinglipid core particlesliposomesnanoemulsionspolymeric nanoparticles

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Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Chemotherapeutic agents possess a low pharmacological index, leading to significant toxicity and risk for cancer patients.
  • Targeted drug delivery presents a promising strategy to mitigate the adverse effects of chemotherapy.

Purpose of the Study:

  • To review clinical studies of various nanoparticle-based drug delivery systems used to concentrate anticancer drugs in neoplastic tissues.
  • To evaluate the efficacy of these systems in reducing drug toxicity and expanding patient eligibility for chemotherapy.

Main Methods:

  • Review of clinical studies involving liposomes, micelles, albumin-based, polymeric, dendritic, and lipid core nanoparticles as anticancer drug carriers.
  • Analysis of studies demonstrating the targeting properties and toxicity reduction capabilities of these nanocarriers.

Main Results:

  • Most reviewed drug delivery systems demonstrated a reduction in drug toxicity.
  • Lipid core nanoparticles (LDE) exhibited potent targeting capabilities by binding to cell lipoprotein receptors and concentrating in neoplastic tissues.
  • LDE showed a particularly strong reduction in toxicity when used with carmustine, etoposide, and paclitaxel.

Conclusions:

  • Drug delivery systems effectively reduce chemotherapy-induced toxicity, broadening the potential patient population for treatment.
  • This includes vulnerable groups like the elderly or those previously treated, who may now be candidates for curative or extended chemotherapy regimens.
  • Nanoparticle-based delivery systems can enable prolonged treatment durations or increased drug dosages, improving therapeutic outcomes.