Related Experiment Video
Updated: Aug 9, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
[Intensification of gas exchange in high-frequency artificial ventilation]
Abstract:
Jet high-frequency artificial ventilation produces oscillations of some parts of the chest wall, which in its turn transmits oscillations to the lung parenchyma. It results in the mix-up of the gas in the alveolar space, which leads to the increase in the gradient of oxygen concentration on the alveolar membranes, thus, augmenting oxygen saturation of the blood. The effect is the same when oscillation artificial ventilation is performed, owing to the provocation of the oscillations amplified by the resonance in the natural acoustic circuit, formed by the adjacent parts of the chest and lung parenchyma. Derangement of the exudative adhesion to the bronchi epithelial tissue intensifies gas exchange, when the oscillations are generated in the lungs. It facilitates the removal of the exudate and lets the air into the previously obstructed parts of the lungs. Clinical studies confirm the effect of the increase in the blood oxygenation (by average 20%) at the feeding air column by pneumatic oscillations in the range of 65 Hz, when traditional artificial ventilation is performed.
More Related Videos
Related Concept Videos
Alterations in Respiration II
In Biot's breathing, the respiratory rate and depth are irregular, alternating between periods of deep gasping and apnea. Common causes include...
External and Internal Respiration
Mechanical Ventilation I: Indication and Settings
Mechanical Ventilation II: Invasive Ventilation
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation
Noninvasive Positive-Pressure Ventilation (NIPPV)
Ventilatory Modes
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...

