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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

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Types of RNA01:20

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Types of RNA01:23

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Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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RNA Interference01:23

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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Phases of Wound Repair01:28

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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[Long non-coding RNA and wound healing].

Y Liu1, D W Liu

  • 1Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.

Zhonghua Shao Shang Za Zhi = Zhonghua Shaoshang Zazhi = Chinese Journal of Burns
|January 4, 2017
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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are key regulators in gene expression and cellular processes. This review explores their crucial roles in wound healing, offering new therapeutic targets for scar treatment.

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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Long non-coding RNAs (lncRNAs) are RNA molecules over 200 nucleotides that regulate gene expression epigenetically, transcriptionally, and post-transcriptionally.
  • lncRNAs are increasingly recognized for their significant roles in cellular processes like proliferation, differentiation, migration, and apoptosis.
  • These molecules are emerging as critical regulators in wound healing, influencing re-epithelialization, angiogenesis, and scar formation.

Purpose of the Study:

  • To review the multifaceted roles of lncRNAs in various stages of wound repair.
  • To elucidate the molecular mechanisms underlying lncRNA involvement in wound healing.
  • To identify lncRNAs as potential therapeutic targets for pathological scars and improved wound healing.

Main Methods:

  • Literature review of recent research on lncRNA function in biological processes.
  • Analysis of studies investigating lncRNA involvement in wound healing stages.
  • Synthesis of current knowledge on lncRNA regulatory networks in tissue repair.

Main Results:

  • lncRNAs significantly impact cell proliferation, differentiation, migration, and apoptosis during wound healing.
  • Specific lncRNAs are shown to modulate key processes like re-epithelialization and angiogenesis.
  • lncRNA dysregulation is linked to pathological scar formation, highlighting their regulatory importance.

Conclusions:

  • lncRNAs represent a novel and critical research area in understanding wound healing.
  • Targeting lncRNAs offers promising therapeutic strategies for preventing and treating abnormal scarring.
  • Further investigation into lncRNA mechanisms can lead to advanced wound care interventions.