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Updated: Feb 8, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Pgi: the ongoing saga of a candidate gene
Christopher W Wheat1, Jason Hill1
1Department of Zoology, Stockholm University, Svante Arrheniusväg 18 B, 10691 Stockholm, Sweden.
Abstract:
Numerous studies have found amino acid variation at the phosphoglucose isomerase (PGI) gene associated with organismal performance and fitness. Here we focus upon recent advances in the study of this gene, highlighting novel species being studied, new tools being used, and emerging insights into the evolutionary dynamics acting on this gene. Our synthesis highlights questions that are coming into focus, as well as the need for attention in specific areas, such as manipulative experiments to establish mechanistic insights and a causative role of allelic variation.
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