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Related Concept Videos

Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

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Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
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Endocarditis IV: Nursing Management01:29

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Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
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Endocarditis I: Introduction01:25

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Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
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Estimation of k and VD of Aminoglycosides01:20

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Aminoglycosides are a class of antibiotics used to treat various bacterial infections. Clinicians must determine the elimination rate constant (k) and volume of distribution (VD) to optimize therapeutic efficacy and minimize toxicity. The k value represents the rate at which the drug is removed from the body, and the VD reflects the degree to which the drug distributes into body tissues. Accurately estimating these parameters allows healthcare professionals to tailor drug dosing to individual...
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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Mitral Stenosis III: Medical Management01:26

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Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Updated: Mar 9, 2026

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Aminoglycosides for Surgically Treated Enterococcal Endocarditis.

Jona M Banzon1, Syed T Hussain2, Steven M Gordon1

  • 1Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio.

Seminars in Thoracic and Cardiovascular Surgery
|January 4, 2017
PubMed
Summary
This summary is machine-generated.

Adding aminoglycosides to standard treatment for enterococcal endocarditis after surgery may improve patient survival. Further research is needed to confirm if this combination therapy is superior to monotherapy.

Keywords:
aminoglycosidesantibioticsinfectioninfective endocarditissurgery

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Area of Science:

  • Infectious Diseases
  • Cardiology
  • Pharmacology

Background:

  • Aminoglycosides are crucial for treating enterococcal infective endocarditis.
  • The efficacy of adding aminoglycosides to cell wall-active agents post-surgery remains uncertain.

Purpose of the Study:

  • To evaluate the impact of adjunctive aminoglycoside therapy on patient outcomes after surgery for enterococcal endocarditis.

Main Methods:

  • A retrospective study included 108 patients who underwent surgery for enterococcal endocarditis (July 2007-July 2014).
  • Propensity score matching and multivariable Cox proportional hazards models were used to compare outcomes between patients receiving and not receiving postoperative aminoglycosides.
  • Key factors adjusted for included age, valve type, comorbidities, and infection characteristics.

Main Results:

  • 37% of patients received postoperative aminoglycoside therapy for a median of 5 days.
  • Adjunctive aminoglycoside therapy was associated with improved survival, though not statistically significant (HR=0.65, 95% CI: 0.32-1.33).
  • Survival benefits were consistent across various subgroups and definitions of aminoglycoside use.

Conclusions:

  • Postoperative antibiotic monotherapy with a cell wall-active agent may be less effective than combination therapy including aminoglycosides for enterococcal endocarditis.
  • The findings suggest a potential benefit of incorporating aminoglycosides into the postoperative treatment regimen.