Related Experiment Video
Updated: Mar 9, 2026
02:28
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
989
Psoriasis and metabolic syndrome in children: current data
A Pietrzak1, E Grywalska2,3, M Walankiewicz2
1Department of Dermatology, Venereology and Paediatric Dermatology, Medical University of Lublin, Lublin, Poland.
Clinical and Experimental Dermatology
|January 4, 2017
Summary
Children with psoriasis show higher rates of metabolic syndrome (MetS) and concerning lipid profiles, including lower HDL cholesterol and higher fasting glucose. Further research is needed to confirm these early signs of MetS in pediatric psoriasis patients.
Area of Science:
- Pediatric Dermatology
- Metabolic Health
- Cardiovascular Risk
Background:
- Cardiovascular and metabolic disorders are not well-established in pediatric psoriasis patients.
- Psoriasis in children may be linked to metabolic complications.
Purpose of the Study:
- To perform a meta-analysis on the prevalence of metabolic disorders in children with psoriasis.
- To synthesize existing research on metabolic health in pediatric psoriasis.
Main Methods:
- Meta-analysis of 7 studies.
- Inclusion of 965 children with psoriasis.
- Random effects model analysis.
Main Results:
- Metabolic syndrome (MetS) prevalence was significantly higher in children with psoriasis compared to healthy controls.
- Children with psoriasis exhibited significantly lower high-density lipoprotein (HDL) cholesterol levels.
- Elevated fasting glucose levels were observed in pediatric psoriasis patients, suggesting early metabolic alterations.
Conclusions:
- Low HDL cholesterol and high fasting glucose may indicate early-stage MetS in pediatric psoriasis.
- A large population-based study is required to fully understand the psoriasis-MetS link in children.
- Investigating environmental, genetic, and immunological factors is crucial for understanding co-occurrence.
Related Concept Videos
01:20Inborn Errors of Metabolism
967
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
967
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
306
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
306
01:24Overview of Lipid Metabolism
6.3K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.3K
01:23Skin Diseases and Disorders
6.0K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
6.0K
01:21Overview of Protein Metabolism
4.4K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
4.4K
01:20Pathophysiology of Diabetes
4.0K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.0K