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Identification and characterization a novel HLA-A allele, A*02:355, by sequence-based typing in a Chinese potential
X-M Nie1,2, Y Zhang2, W-B Qiao2
1Department of Central Laboratory, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China.
Abstract:
The new allele A*02:355 differs from A* 02:03:01 at positions 98 (T→A) and 102(A→C) resulting in an amino acid exchange F9→T. Interallelic sequence exchange is more likely the mechanism of its origination. The amino acid replacement influences the HLA peptide binding cleft and might have significant functional effects.
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