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Functional and histopathological renal changes induced in rats by Bothrops jararaca venom
N A Rezende1, C F Amaral, E A Bambirra
1Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Summary
Bothular jararaca venom induces acute kidney injury in rats, evidenced by reduced kidney function and tubule damage. Hemodynamic changes are implicated in the venom
Area of Science:
- Nephrology
- Toxicology
- Pathology
Background:
- Snakebites can cause systemic envenomation.
- Renal complications are a significant concern following envenomation by Bothrops species.
Purpose of the Study:
- To investigate the functional and histopathological renal effects of Bothrops jararaca venom in adult female rats.
Main Methods:
- Rats received Bothrops jararaca venom intraperitoneally.
- Renal function parameters (glomerular filtration rate, renal plasma flow, etc.) and plasma creatinine were measured.
- Kidney histopathology was assessed via light microscopy.
Main Results:
- Venom administration led to acute renal failure, decreased renal plasma flow, and reduced mean arterial pressure.
- Histopathology revealed mesangial matrix proliferation and tubular degenerative changes.
- Decreased glomerular filtration rate, osmolar clearance, and altered sodium excretion were observed.
Conclusions:
- Bothrops jararaca venom causes significant functional and structural renal damage in rats.
- Hemodynamic alterations likely contribute to the pathogenesis of venom-induced nephrotoxicity.