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A systematic review of factors that influence treatment adherence in paediatric oncology patients

X T W Goh1, Y B Tan1, T Thirumoorthy1,2

  • 1Duke-NUS Medical School, Singapore, Singapore.

Journal of Clinical Pharmacy and Therapeutics
|January 4, 2017
PubMed

Insights

Treatment adherence in paediatric cancer is complex, influenced by 17 factors across five categories: patient/caregiver, therapy, condition, health system, and social/economic. A baby bear model aids understanding and early intervention for non-adherence.

Area of Science:

  • Pediatric Oncology
  • Pharmacology
  • Health Services Research

Background:

  • Treatment adherence is crucial for optimal outcomes in pediatric cancer management.
  • Adherence in children presents unique challenges compared to adults.
  • Identifying factors influencing adherence is key to improving treatment success.

Purpose of the Study:

  • To systematically review the literature and identify factors associated with treatment adherence in pediatric oncology.
  • To develop a model and framework for clinicians to assess and address adherence issues.

Main Methods:

  • A comprehensive literature search was conducted using relevant keywords across electronic databases.
  • 1036 articles were initially reviewed, with 39 ultimately included in the systematic review.

Main Results:

  • Seventeen distinct factors influencing treatment adherence were identified.
  • These factors were categorized into five main domains: patient/caregiver, therapy, condition, health system, and social/economic.
  • A 'baby bear model' was proposed to visualize these influencing factors.

Conclusions:

  • The identified factors provide a framework for understanding pediatric cancer treatment adherence.
  • Clinicians can utilize the proposed framework and questions to identify at-risk patients for early intervention.
  • Awareness of interacting factors and context-specific relevance (e.g., socioeconomic status, location) is vital for effective adherence strategies.
Abstract

Keywords:
adherencecompliancefactorsoncologypaediatric

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