Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

1.1K
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

737
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
737
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

843
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
843
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.3K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.3K
Schizophrenia01:17

Schizophrenia

1.4K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.4K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

646
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
646

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GWAS analysis of a depression cohort defined by an EHR-phenotyping algorithm reveals the role of immune regulations in depression risk.

Frontiers in genetics·2026
Same author

Providers' receptivity and perceived barriers to implement written exposure therapy for PTSD: Qualitative provider and leader interviews across six civilian health care systems.

Psychological trauma : theory, research, practice and policy·2026
Same author

Patient Insights to Improve Naloxone Access and Decision Support.

The Permanente journal·2026
Same author

Pediatric healthcare worker perspectives on implementation of a secure firearm storage program: a qualitative study.

BMC pediatrics·2026
Same author

Impact of the Transition from ICD9-CM to ICD10-CM on Measuring Rates of Child and Adolescent Self-harm in Nine Health Systems.

Academic pediatrics·2026
Same author

Evaluating the feasibility and scalability of longitudinal placements for undergraduate pharmacy students in primary care.

Currents in pharmacy teaching & learning·2026

Related Experiment Video

Updated: Mar 9, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K

First Presentation With Psychotic Symptoms in a Population-Based Sample.

Gregory E Simon1, Karen J Coleman1, Bobbi Jo H Yarborough1

  • 1Dr. Simon, Ms. Operskalski, Dr. Stewart, and Dr. Carrell are with the Group Health Research Institute, Group Health Cooperative, Seattle (e-mail: simon.g@ghc.org ). Dr. Coleman is with the Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena. Dr. Yarborough and Dr. Lynch are with the Center for Health Research, Kaiser Permanente, Portland, Oregon. When this work was done, Ms. Hunkeler, who is now retired, was with the Division of Research, Kaiser Permanente, Oakland, California. Dr. Beck is with the Institute for Health Research, Kaiser Permanente of Colorado, Denver.

Psychiatric Services (Washington, D.C.)
|January 4, 2017
PubMed
Summary
This summary is machine-generated.

First-onset psychosis incidence is higher than previously estimated, particularly in younger adults. Early intervention programs need to account for diverse care settings and presentations beyond traditional mental health services.

Keywords:
EpidemiologyPsychosesSchizophrenia

More Related Videos

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.0K

Related Experiment Videos

Last Updated: Mar 9, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

15.6K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.2K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

8.0K

Area of Science:

  • Psychiatry
  • Epidemiology
  • Public Health

Background:

  • Early intervention is crucial for first-onset psychosis.
  • Population-based data on incidence and care settings are needed for effective program implementation.

Purpose of the Study:

  • To estimate the true incidence of first-onset psychotic symptoms.
  • To identify the care settings where individuals first present with psychosis.

Main Methods:

  • Utilized electronic health records from five health care systems (2007-2013).
  • Identified first psychosis diagnoses in individuals aged 15-59.
  • Confirmed diagnoses through medical record review for a random sample.

Main Results:

  • Estimated true incidence rates were 86 per 100,000 for ages 15-29 and 46 per 100,000 for ages 30-59.
  • Confirmation rates varied significantly by age and care setting.
  • Higher incidence observed when including all care settings.

Conclusions:

  • Incidence of first-onset psychosis is higher than previously reported.
  • Early intervention programs must consider presentations in outpatient and primary care settings.
  • Programs should also address the needs of individuals presenting after age 30.