Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chemical and Solubility Equilibria

Chemical and Solubility Equilibria

The free energy change associated with dissolving a solute in a liter of solvent is called the free energy of a solution, ΔGsolution. The overall ΔGsolution is expressed as the balance of ΔGinteraction against the always-favorable free-energy of mixing, ΔGmixing. Solution formation is favorable if ΔGsolution is less than zero, whereas it is unfavorable if ΔGsolution is greater than zero. In short, for a solution to form and complete dissolution to take place,...

Chemical Equilibria: Systematic Approach to Equilibrium Calculations

Chemical Equilibria: Systematic Approach to Equilibrium Calculations

Equilibrium calculations for systems involving multiple equilibria are often complex. For example, to calculate the solubility of a sparingly soluble salt in an aqueous solution in the presence of a common ion, one must consider all the equilibria in this solution. Calculations for these systems can be complicated and tedious, so a systematic approach with a series of steps is often helpful. The process is detailed below.
The first step is to identify all the chemical reactions involved, The...

The Equilibrium Binding Constant and Binding Strength

The Equilibrium Binding Constant and Binding Strength

The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Structure-dependent incorporation of terpenes into amphiphilic Poly(2-oxazoline) micelles.

Biomedical microdevices·2026

Same author

Multiscale-Aware Graph Embedding Approach Uncovers LC-61, a Potent Anti-<i>Leishmania infantum</i> Compound.

Journal of chemical information and modeling·2026

Same author

Multimodal Cross-Attentive Graph-Based Framework for Predicting In Vivo Endocrine Disruptors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Same author

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2.

Journal of chemical information and modeling·2026

Same author

Adaptive Machine Learning Framework for Optimizing the Affinity Purification of Adeno-Associated Viral Vectors.

Biotechnology and bioengineering·2026

Same author

Medicines, Diseases, Indications, and Contraindications (MeDIC): a foundational resource to support drug repurposing.

Nucleic acids research·2025

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Chembench: A Publicly Accessible, Integrated Cheminformatics Portal.

Stephen J Capuzzi¹, Ian Sang-June Kim¹, Wai In Lam¹

¹Laboratory for Molecular Modeling, Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, and ‡Department of Computer Science, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

Journal of Chemical Information and Modeling

|January 4, 2017

Summary

Chembench, a web portal for cheminformatics, offers updated tools for drug design and toxicology. It provides accessible, integrated services for analyzing chemical genomics data, supporting open science initiatives.

More Related Videos

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Related Experiment Videos

Last Updated: Mar 9, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Area of Science:

Cheminformatics
Chemical Genomics
Computational Toxicology

Background:

Increasing availability of public chemical genomics data necessitates accessible cheminformatics tools.
Chembench is a pioneering, integrated web portal for cheminformatics research.
The portal has seen extensive use since its 2008 launch, with over 1 million accesses.

Purpose of the Study:

To report recent updates and improvements to the Chembench web portal.
To enhance the usability, efficiency, accuracy, and accessibility of cheminformatics tools.
To support computer-assisted drug design and computational toxicology research.

Main Methods:

Development and integration of updated cheminformatics tools and services.
Enhancements focused on improving user experience and computational performance.
Ensuring broad accessibility for researchers worldwide.

Main Results:

Chembench now offers increased simplicity of use and computational efficiency.
Improvements in accuracy and accessibility of a wide range of tools.
Continued free accessibility for the scientific community.

Conclusions:

Chembench remains a valuable, freely accessible resource for cheminformatics research.
Recent updates enhance its utility for drug design and toxicology.
The portal supports open science by providing integrated cheminformatics services.