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Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
New N-substituted hydrazones, derivatives of uridyl aldehyde
Katarzyna Kral1, Tadeusz Bieg1, Agnieszka Kudelko2
1a Department of Organic Chemistry , Bioorganic Chemistry and Biotechnology, Silesian University of Technology , Gliwice , Poland.
Abstract:
N-substituted isomeric hydrazones of uridyl aldehyde have been synthesized. The occurrence of the dominant E isomers with respect to the azomethine group was confirmed by means of NMR spectroscopy. Synthesized hydrazones feature an acetonide moiety as a protection of two hydroxyl groups on the ribose part. The attempt to remove the protecting group resulted in an azo-hydrazone tautomeric mixture. The described compounds may be valuable chiral ligands for metal chelation. Assessment of manganese(II) ion affinity to one selected hydrazone was performed.
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