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Glycine irrigation and urinary oxalate excretion
1Department of Anaesthesiology, Huddinge University Hospital, Sweden.
British Journal of Urology
|September 1, 1989
Summary
Glycine irrigation during transurethral prostatic surgery does not increase urinary oxalate levels post-operation. This study investigated glycine
Area of Science:
- Nephrology
- Urology
- Biochemistry
Background:
- Urinary oxalate is a key factor in kidney stone formation.
- Glycine is an amino acid with potential metabolic effects.
- Transurethral prostatic resection (TURP) involves fluid irrigation, raising questions about irrigant absorption and metabolic consequences.
Purpose of the Study:
- To evaluate the short-term impact of glycine supplementation on urinary oxalate excretion.
- To assess the safety and effect of glycine irrigation during TURP on postoperative urinary oxalate levels.
Main Methods:
- Intravenous infusion of glycine solutions (2.2% or 1.5% with 1% ethanol) or mannitol (control) in healthy volunteers.
- Volumetric measurement of irrigant absorption during glycine irrigation in 9 patients undergoing TURP.
Main Results:
- Intravenous glycine infusion did not significantly alter urinary oxalate excretion in healthy volunteers.
- Glycine irrigation in TURP patients showed minimal irrigant absorption (0-2.71 L).
- Postoperative urinary oxalate levels remained unaffected by glycine irrigation.
Conclusions:
- Glycine irrigation is a safe option for transurethral prostatic resection.
- Glycine irrigation does not lead to elevated urinary oxalate levels in the early postoperative period following TURP.