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Related Experiment Videos

Obstructing carcinomas of the colon.

J W Serpell1, F T McDermott, H Katrivessis

  • 1Department of Surgery, Monash University, Alfred Hospital, Victoria, Australia.

The British Journal of Surgery
|September 1, 1989
PubMed
Summary

Completely obstructing colonic cancer, found in 16.3% of cases, is associated with advanced tumors and poorer survival rates. These aggressive cancers have higher recurrence rates even after curative resection.

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Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Colonic carcinoma presents a significant health challenge with varying prognoses.
  • Obstructing colonic cancer is often associated with a poorer patient outlook.
  • Understanding the factors contributing to poor prognosis in obstruction is crucial for improving outcomes.

Purpose of the Study:

  • To analyze a large cohort of colonic carcinoma cases to identify reasons for the poor prognosis in obstructing colonic cancer.
  • To compare tumor stage, resection rates, recurrence, and survival between obstructing and non-obstructing colonic cancers.

Main Methods:

  • Retrospective analysis of 908 cases of colonic carcinoma.
  • Categorization of cases based on the presence and degree of obstruction (complete, partial, none).

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  • Statistical comparison of tumor stage (Dukes'), curative resection rates, recurrence incidence, and 5-year cancer-specific survival.

    • Main Results:

    • Complete obstruction was present in 16.3% of cases.
    • Completely obstructing tumors were more advanced (fewer Dukes' A, more advanced stages) compared to non-obstructing tumors.
    • Curative resection rates were lower (50.7% vs. 70.6%), recurrence higher (P<0.01), and 5-year survival significantly reduced (31.8% vs. 59.1%) in completely obstructing cancers.

    Conclusions:

    • Completely obstructing colonic cancers demonstrate more aggressive behavior compared to non-obstructing tumors.
    • The increased incidence of advanced tumors and local recurrence contributes to the poorer prognosis.
    • Early detection and management strategies are vital for improving survival in obstructing colonic cancers.