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Primate spinothalamic cell responses to ureteral occlusion
1Department of Physiology, Thomas Jefferson University, Philadelphia, PA 19107.
Brain Research
|September 4, 1989
Summary
Occluding the upper ureter activates spinothalamic tract (STT) neurons in monkeys. These neurons likely contribute to the sensation and referral of renal pain.
Area of Science:
- Neuroscience
- Physiology
Background:
- The spinothalamic tract (STT) transmits pain and temperature information to the brain.
- Understanding the neural pathways involved in renal pain is crucial for effective pain management.
Purpose of the Study:
- To investigate the effect of ureteral occlusion on the activity of thoracolumbar spinothalamic tract (STT) neurons.
- To determine if STT neurons respond to stimuli associated with renal colic.
Main Methods:
- Experiments were conducted on anesthetized Macaca fascicularis monkeys.
- Extracellular unit recordings were used to monitor STT neuron activity in the T11-L1 segments.
- The uppermost portion of the ureter was occluded to observe neuronal responses.
Main Results:
- Ureteral occlusion significantly increased the activity of 16 out of 38 recorded STT neurons.
- Responsive neurons were typically wide dynamic range cells and received input from both A delta- and C-afferent renal fibers.
- Peak neuronal responses occurred within seconds of occlusion onset, with subsequent adaptation.
Conclusions:
- Occlusion of the upper ureter excites specific thoracolumbar STT neurons.
- These activated STT neurons are likely involved in the perception of renal pain and its characteristic referral patterns to the flank and abdomen.