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Ontogenesis of monoamine oxidase-A and -B in the human brain frontal cortex
J Kornhuber1, C Konradi, F Mack-Burkhardt
1Department of Psychiatry, University of Würzburg, F.R.G.
Brain Research
|October 9, 1989
Abstract:
The effect of several antemortem and postmortem factors (patients' age, sex, postmortem delay, storage time, laterality and brain weight) on both monoamine oxidase-A (MAO-A) and -B (MAO-B) activity was investigated in the frontal cortex of human brains. The MAO-A activity decreases rapidly during the first two years of life and remains constant thereafter. In contrast, the MAO-B activity keeps unchanged during early childhood and raises during advanced age. These findings seem to be consistent with a genetic regulation and a variation in cell type assembling during brain development and aging.