[Studies on the effect of liver cytosol on experimental acute hepatic failure in the rat]

This paper reports that dog regenerating liver cytosol (DRLC) and human fetal liver cytosol were found capable of increasing the survival rate of rats with liver failure induced by D-galactosamine (Ga1N). It was noted that the potential substances for hepatic failure are not species specific. Nevertheless this is a characteristic of the growing liver. The experimental results suggested that the effects of growing liver cytosol on liver regeneration were through three ways: 1. Hepatocytes DNA synthesis was increased. 2. Phagocytosis function of Kupffer cells was elevated which might prevent damage of liver cells by intestinal endotoxin. 3. Insulin secretion and its combination with hepatocytes were increased.