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Updated: Mar 9, 2026
10:24
Neutron Radiography and Computed Tomography of Biological Systems at the Oak Ridge National Laboratory's High Flux Isotope Reactor
Published on: May 7, 2021
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A 13C(d,n)-based epithermal neutron source for Boron Neutron Capture Therapy
1Gerencia de Investigación y Aplicaciones, CNEA, Av. Gral. Paz 1499 (B1650KNA), San Martín, Buenos Aires, Argentina; CONICET, Av. Rivadavia 1917 (C1033AAJ), Buenos Aires, Argentina; Escuela de Ciencia y Tecnología, Universidad Nacional de San Martín, M. de Irigoyen 3100 (1650), San Martín, Buenos Aires, Argentina.
Summary
The 13C(d,n)14N reaction shows promise for Boron Neutron Capture Therapy (BNCT) using low-energy accelerators. This study demonstrates its potential for delivering therapeutic neutron beams effectively.
Area of Science:
- Nuclear Physics
- Medical Physics
- Radiation Oncology
Background:
- Boron Neutron Capture Therapy (BNCT) requires compact neutron sources for clinical use.
- Low-energy particle accelerators are suitable for in-hospital siting.
- The 13C(d,n)14N nuclear reaction is a potential neutron source for BNCT.
Purpose of the Study:
- To evaluate the therapeutic potential of neutron beams produced by the 13C(d,n)14N reaction.
- To assess the feasibility of using a 1.45MeV deuteron beam for BNCT.
- To optimize neutron beam characteristics for effective tumor irradiation.
Main Methods:
- Computational optimization of a Beam Shaping Assembly (BSA).
- MCNP simulations of depth dose profiles in a Snyder head phantom.
- Determination of BSA configuration to maximize tumor dose and penetration depth while minimizing healthy tissue dose.
Main Results:
- Therapeutic doses achieved up to ~6cm depth.
- Peak doses of 57Gy-Eq possible with 2x1h fractionated irradiations.
- Acceptable tumor doses feasible with a single 1h irradiation.
Conclusions:
- The 13C(d,n)14N reaction is a viable option for accelerator-based BNCT.
- Neutron beams generated are comparable to other accelerator sources.
- This reaction supports the development of in-hospital BNCT neutron sources.
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