Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

7.2K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relapsed Extranodal NK/T-Cell Lymphoma Presenting as Unilateral Third Cranial Nerve Palsy: A Rare Case Report.

Neuro-ophthalmology (Aeolus Press)·2026
Same author

Effective Core Potentials for Calculations of Continuum Spectra of Molecules Using the Molecular R-Matrix Method.

Journal of chemical theory and computation·2026
Same author

A rare case of peri-ocular congenital infiltrating lipomatosis with associated schizencephaly.

Orbit (Amsterdam, Netherlands)·2025
Same author

External versus endonasal dacryocystorhinostomy: a single-centre United Kingdom study of 512 consecutive operations.

Orbit (Amsterdam, Netherlands)·2025
Same author

[Smoking and eye diseases].

Die Ophthalmologie·2025
Same author

Linking mitochondria, fatty acids, and hematopoietic stem cell expansion during infection: implications for aging and metabolic diseases.

Stem cells (Dayton, Ohio)·2025

Related Experiment Video

Updated: Mar 9, 2026

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
07:00

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

6.6K

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

Manar S Shafat1, Thomas Oellerich2,3,4, Sebastian Mohr2

  • 1Department of Molecular Haematology, Norwich Medical School, The University of East Anglia, Norwich Research Park, Norwich, United Kingdom.

Blood
|January 5, 2017
PubMed
Summary
This summary is machine-generated.

Acute myeloid leukemia (AML) cells reprogram bone marrow fat cells (adipocytes) to support their growth and survival. Targeting these tumor-host interactions, specifically fatty acid metabolism and FABP4, offers a novel therapeutic strategy for AML.

More Related Videos

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

9.6K

Related Experiment Videos

Last Updated: Mar 9, 2026

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation
07:00

Dual Effects of Melanoma Cell-derived Factors on Bone Marrow Adipocytes Differentiation

Published on: August 23, 2018

6.6K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

2.0K
Modeling Chemotherapy Resistant Leukemia In Vitro
08:41

Modeling Chemotherapy Resistant Leukemia In Vitro

Published on: February 9, 2016

9.6K

Area of Science:

  • Oncology
  • Cancer Biology
  • Metabolic Research

Background:

  • Most acute myeloid leukemia (AML) patients succumb to the disease despite current treatments.
  • Tumor-host interactions are crucial for cancer cell survival and proliferation.
  • Bone marrow adipose tissue is abundant and may influence leukemia progression.

Purpose of the Study:

  • To investigate the role of adipocyte-leukemia cell interactions in AML growth and survival.
  • To determine if targeting the tumor microenvironment, specifically adipocytes, can be a therapeutic strategy for AML.

Main Methods:

  • Utilized in vivo and in vitro AML models.
  • Examined metabolic alterations in adipocytes induced by AML blasts.
  • Assessed the impact of inhibiting fatty acid metabolism and FABP4 on AML proliferation and survival.
  • Investigated carnitine palmitoyltransferase IA inhibition in a patient-derived xenograft model.

Main Results:

  • Bone marrow adipocytes were found to support AML survival and proliferation.
  • AML blasts induce adipocyte lipolysis, providing fatty acids to leukemia cells.
  • Fatty acid binding protein-4 (FABP4) is upregulated in cocultured adipocytes and AML cells.
  • Inhibition of FABP4 and carnitine palmitoyltransferase IA improved survival in AML models.

Conclusions:

  • AML actively reprograms bone marrow adipocytes to create a protumoral microenvironment.
  • Targeting adipocyte-derived fatty acids and FABP4 presents a promising therapeutic avenue for AML.