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Lipid Profile of Children with Malaria by Plasmodium vivax

Rosa Maria Dias1, Jose Luiz Fernandes Vieira1, Bianca da Conceição Cabral1

  • 1Health Science Institute, Pará Federal University, Belém, PA, Brazil.

Journal of Tropical Medicine
|January 5, 2017
PubMed

Insights

Pediatric Plasmodium vivax malaria causes significant, temporary lipid profile changes in children, including lower cholesterol and higher triglycerides. These lipid abnormalities are not linked to parasite levels or prior malaria history.

Area of Science:

  • Pediatric infectious diseases
  • Clinical biochemistry
  • Parasitology

Background:

  • Lipid profile alterations are common in adult malaria patients.
  • Limited research exists on lipid abnormalities in children with Plasmodium vivax malaria.
  • Continuous exposure to P. vivax in children warrants investigation into lipid changes.

Purpose of the Study:

  • To investigate lipid abnormalities in children diagnosed with P. vivax malaria.
  • To determine if parasite count correlates with lipid levels upon admission.
  • To assess the association between malaria history and lipid profiles in pediatric patients.

Main Methods:

  • Study included 75 children; 43 had confirmed P. vivax infection.
  • Blood samples collected at admission, day 7, and day 14.
  • Evaluated triglycerides, VLDL, total cholesterol, HDL, and LDL levels using colorimetric methods.

Main Results:

  • Children with malaria showed significantly lower total cholesterol, LDL, and HDL levels.
  • Elevated VLDL and triglyceride levels were observed in children with malaria.
  • These lipid changes were transient and not associated with parasite count or malaria history.

Conclusions:

  • P. vivax infection in children causes significant, transient lipid abnormalities.
  • Lipid profile changes occur even with low parasite levels and mild symptoms.
  • No correlation found between lipid abnormalities, parasitemia, or previous malaria episodes.

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