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Updated: Mar 9, 2026

A Nanobar-Supported Lipid Bilayer System for the Study of Membrane Curvature Sensing Proteins in vitro
Published on: November 30, 2022
The Role of BAR Domain Proteins in the Regulation of Membrane Dynamics
T B Stanishneva-Konovalova1, N I Derkacheva2, S V Polevova1
1Lomonosov Moscow State University, Faculty of Biology, Leninskie Gory 1, Bld 12, Moscow, 119234 , Russia.
Abstract:
Many cellular processes are associated with membrane remodeling. The BAR domain protein family plays a key role in the formation and detection of local membrane curvatures and in attracting other proteins, including the regulators of actin dynamics. Based on their structural and phylogenetic properties, BAR domains are divided into several groups which affect membrane in various ways and perform different functions in cells. However, recent studies have uncovered evidence of functional differences even within the same group. This review discusses the principles underlying the interactions of different groups of BAR domains, and their individual representatives ,with membranes.
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