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Ofloxacin Induced Angioedema: A Rare Adverse Drug Reaction

Gautam Rawal1, Sankalp Yadav2, Raj Kumar3

  • 1Attending Consultant-Respiratory Intensive Care, Max Super Specialty Hospital , Saket, New Delhi, India .

Journal of Clinical and Diagnostic Research : JCDR
|January 5, 2017
PubMed

Insights

A rare angioedema adverse drug reaction (ADR) occurred in a young woman after taking Ofloxacin. Prompt treatment with corticosteroids and antihistamines led to successful recovery, highlighting the importance of ADR monitoring.

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Public Health

Background:

  • Adverse Drug Reactions (ADRs) to antimicrobials are a significant public health concern.
  • Fluoroquinolones, including Ofloxacin, are commonly prescribed antibiotics.
  • Hypersensitivity reactions to fluoroquinolones are infrequent, occurring in 0.4% to 2% of cases.

Observation:

  • A 24-year-old female presented with lip angioedema following Ofloxacin ingestion for diarrhea.
  • Clinical evaluation and normal lab results supported the diagnosis of an Ofloxacin-induced hypersensitivity reaction.
  • The patient responded well to treatment with corticosteroids and antihistamines.

Findings:

  • The case confirms Ofloxacin as a potential cause of rare hypersensitivity reactions like angioedema.
  • Successful management involved standard anti-allergy medications.
  • The incidence of such reactions underscores the need for vigilance.

Implications:

  • Enhanced pharmacovigilance and mandatory ADR reporting by healthcare professionals are crucial.
  • Promoting judicious Ofloxacin use can improve drug safety.
  • Reducing ADRs minimizes associated patient morbidity and mortality.
Keywords:
FluoroquinolonesHypersensitivityPharmacovigilance

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