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Updated: Mar 9, 2026
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Epigenetics and Periodontitis: A Contemporary Review
Geetha Ari1, Sandhya Cherukuri2, Ambalavanan Namasivayam3
1Reader, Department of Periodontology, Meenakshi Ammal Dental College and Hospital , Chennai, Tamil Nadu, India .
Journal of Clinical and Diagnostic Research : JCDR
|January 5, 2017
Summary
Periodontitis, an inflammatory gum disease, involves pathogenic microorganisms and genetic factors. Epigenetic modifications may offer new insights for early detection and treatment strategies.
Area of Science:
- Periodontology
- Genetics
- Epigenetics
Background:
- Periodontitis is a significant oral inflammatory disease affecting tooth-supporting structures.
- Pathogenic microorganisms contribute to disease susceptibility and recurrence.
- Genetic variations, particularly in inflammatory response genes, are linked to increased periodontitis risk.
Approach:
- Investigating the role of epigenetic modifications in gene regulation.
- Exploring how environmental stimuli influence gene expression in periodontitis.
- Examining molecular mechanisms underlying disease development and progression.
Key Points:
- Epigenetic mechanisms regulate genes involved in various diseases, including inflammatory conditions.
- Environmental factors can modify gene expression through epigenetic changes.
- Understanding these epigenetic influences is crucial for periodontitis research.
Conclusions:
- Epigenetic modifications represent a potential avenue for understanding periodontitis.
- Early detection of susceptibility may be enhanced through epigenetic analysis.
- Future periodontal disease treatment and prevention strategies could leverage epigenetic insights.
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