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A systematic approach to cancer: evolution beyond selection.

William B Miller1, John S Torday2

  • 1Independent Researcher, Paradise Valley, AZ, 85253, USA. wbmiller1@cox.net.

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Summary
This summary is machine-generated.

This study proposes cognition-based evolution as a new model for cancer, viewing neoplastic cells as self-aware agents driving cancer progression. This perspective enhances understanding of tumor development and resource utilization.

Keywords:
AneuploidyCancerCellular cognitionHologenomeInformation fieldsNiche constructionPhenotypeSelf-referenceStigmergyTissue ecology

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Area of Science:

  • Oncology
  • Evolutionary Biology
  • Cell Biology

Background:

  • Cancer is traditionally viewed as a pathological process driven by genetic mutations and Darwinian selection.
  • Existing models focus on chromosomal aberrations and clonal expansion within cellular ecosystems.

Purpose of the Study:

  • To introduce and explore cognition-based evolution as an alternative framework for understanding cancer development.
  • To re-evaluate neoplastic cells as self-referential agencies with purposive roles in tissue microenvironments.

Main Methods:

  • Conceptual analysis and theoretical modeling of cancer progression.
  • Applying principles of cognition and participant/observer status to neoplastic cells.
  • Examining the role of evolutionary stages and ecological resource utilization.

Main Results:

  • Neoplastic cells, regardless of karyotype, can be viewed as active participants in their tissue ecology.
  • The participant/observer status of neoplastic cells influences their interaction with the microenvironment.
  • Cognition-based evolution offers a novel perspective on how neoplastic cells achieve proliferation.

Conclusions:

  • Cancer progression may be better understood through a lens of cognition-based evolution rather than solely Darwinian selection.
  • Viewing neoplastic cells as self-aware entities provides new insights into tumor behavior and adaptation.
  • This framework suggests that flexible re-connection with progenitor evolutionary stages enhances neoplastic proliferation.