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Nanoengineered strategies for siRNA delivery: from target assessment to cancer therapeutic efficacy

Dinesh Kumar Mishra1, Neelam Balekar2, Pradyumna Kumar Mishra3

  • 1IPS Academy, College of Pharmacy, A. B. Road, Indore, MP, 452 012, India. dineshdops@gmail.com.

Drug Delivery and Translational Research
|January 5, 2017
PubMed

Insights

RNA interference (RNAi) therapy shows promise for cancer treatment by delivering small interfering RNA (siRNA) to silence genes. Developing effective nanoengineered delivery systems is crucial to overcome delivery challenges in the tumor microenvironment.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • RNA interference (RNAi) offers potential for targeted gene silencing in cancer therapy.
  • Delivery of small interfering RNA (siRNA) is limited by the tumor microenvironment and physiological barriers.

Purpose of the Study:

  • To review gene-silencing mechanisms and challenges in siRNA delivery for cancer therapeutics.
  • To explore nanocarrier systems for effective siRNA delivery into cancer cells.

Main Methods:

  • Literature review of gene-silencing mechanisms.
  • Analysis of challenges in siRNA delivery.
  • Examination of nanocarrier design and delivery strategies.
  • Overview of clinical trials and translational prospects.

Main Results:

  • Nanoengineered delivery systems are essential for overcoming siRNA delivery barriers.
  • Various nanocarrier systems are being developed and validated for siRNA delivery.
  • Ongoing clinical trials are evaluating the efficacy of siRNA-mediated cancer therapeutics.

Conclusions:

  • Effective nanoengineered delivery systems are critical for realizing the potential of siRNA cancer therapeutics.
  • Further research and clinical validation are needed to translate siRNA technology into effective cancer treatments.
Keywords:
Drug deliveryNanomedicineOncotherapyRNA interferenceTranslational research

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