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Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
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RNA synthesis is associated with multiple TBP-chromatin binding events

Hussain A Zaidi1, David T Auble1, Stefan Bekiranov1

  • 1Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Scientific Reports
|January 5, 2017
PubMed
Summary

Competition ChIP measures transcription factor (TF) turnover. This study models TF-chromatin binding to find TATA-binding protein (TBP) residence times, revealing multiple binding events per RNA molecule.

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