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Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors
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Mechanically Controlled Electron Transfer in a Single-Polypeptide Transistor.

Sheh-Yi Sheu1, Dah-Yen Yang2

  • 1Department of Life Sciences, Institute of Genome Sciences and Institute of Biomedical Informatics, National Yang-Ming University, Taipei 112, Taiwan.

Scientific Reports
|January 5, 2017
PubMed
Summary
This summary is machine-generated.

Researchers developed a protein electron transfer (ET) logic gate using mechanically driven polypeptide motion. This approach reveals peptide ET mechanisms, influenced by chirality, helix handedness, and water interactions, offering insights for nanoelectronic devices.

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Area of Science:

  • Nano-bio electronics
  • Molecular electronics
  • Biophysics

Background:

  • Proteins offer versatile structures and specific functions for nano-bio electronic devices.
  • Challenges in quantum transport measurements hinder understanding of protein electron transfer (ET) pathways and mechanisms due to technical limitations.
  • Precisely determining molecular orientation, moieties, surroundings, and temperature is difficult.

Purpose of the Study:

  • To investigate protein electron transfer (ET) mechanisms.
  • To develop a logic gate with ON and OFF states using protein ET.
  • To explore the influence of mechanical polypeptide motion on ET.

Main Methods:

  • Calculated transmission spectra of peptide-based molecular junctions.
  • Mechanically drove polypeptide flip-flop motion.
  • Analyzed electrical current and conductance.

Main Results:

  • Demonstrated a logic gate with ON and OFF states based on protein ET.
  • Observed that peptide ET follows a non-collinear (NC) asymmetric process.
  • Found ET depends on amino acid chirality, α-helical handedness, and the number/type of water molecules and H-bonds.

Conclusions:

  • Provided a rational mechanism for peptide ET.
  • Highlighted the dependence of ET on molecular structure and environment (chirality, handedness, water).
  • Suggested polypeptides as candidates for logic nano devices.