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Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

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Related Experiment Video

Updated: Mar 9, 2026

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

Published on: June 9, 2017

Neural stem cells in lead toxicity.

W-W Chen¹, X Zhang, W-J Huang

¹Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China. 85252095@Qq.com.

European Review for Medical and Pharmacological Sciences

|January 5, 2017

Summary

This summary is machine-generated.

Prenatal lead exposure harms neural stem cells (NSCs), causing lasting cognitive and behavioral deficits. This review details lead toxicity mechanisms to aid in developing new therapeutics for neurodevelopmental disorders.

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Last Updated: Mar 9, 2026

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing

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Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

Area of Science:

Neuroscience
Developmental Biology
Toxicology

Background:

Lead (Pb) exposure during critical neurodevelopmental periods causes irreversible cognitive and behavioral impairments.
Multipotent neural stem cells (NSCs) are primary targets of lead toxicity.
Understanding lead's molecular impact is crucial for mitigating neurodevelopmental harm.

Purpose of the Study:

To review the molecular mechanisms underlying lead-induced neurotoxicity.
To elucidate the effects of lead on neural stem cells and the nervous system.
To provide insights for developing novel therapeutic strategies against lead neurotoxicity.

Main Methods:

Literature review of existing research on lead neurotoxicity.
Analysis of molecular pathways affected by lead exposure.
Synthesis of data on the impact of lead on neural stem cell function.

Main Results:

Lead disrupts fundamental cellular processes in neural stem cells.
Exposure leads to long-term alterations in cognitive function and behavior.
Specific molecular targets and pathways of lead toxicity are identified.

Conclusions:

Lead exposure poses significant risks to neurodevelopment, primarily through its effects on NSCs.
Further research into molecular mechanisms can guide the development of targeted interventions.
Effective management strategies are needed to address prenatal lead exposure and its consequences.