[Nonlinear theophylline kinetics in a boy on long-term theophylline therapy for bronchial asthma. Case report]

On the case of a 13-year-old boy the authors demonstrate the possible non-linear relationship between long-term administration of theophylline and its serum concentrations which implies the danger of induction of limital to toxic concentrations of the drug in the blood stream when the doses are increased as required.