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The risk factors and pattern of cerebral microbleeds in Parkinson's disease
Dian He1,2, Chun-Feng Liu1,3, Lan Chu2,3
1a Department of Neurology , The Second Affiliated Hospital of Soochow University , Soochow University , Suzhou , China.
Background And Purpose:
Cerebral microbleeds (CMBs) in Parkinson's disease (PD) have been reported recently and concerned increasingly. Our aim was to investigate the risk factors and pattern of CMBs in patients with PD, as well as the influence of risk factors on the pattern of CMBs.
Methods:
We retrospectively collected medical and imaging data of 247 patients who underwent brain susceptibility-weighted imaging. Logistic regression analyses were performed to determine the risk factors of CMBs. The frequency and amount of CMBs in different locations between patients with and without risk factors were analyzed.
Results:
Of the 247 patients with PD, 39 (15.79%) had CMBs, 27 (69.23%) had lobar CMBs, 20 (51.28%) had deep CMBs and 17 (43.59%) had infratentorial CMBs. A history of cerebral ischemic events was independently associated with the presence of CMBs (odds ratio (OR) 4.485 [95% CI 2.150-9.356]; p = 0.000), especially with lobar and deep CMBs. Hypertension and Hoehn and Yahr score were also associated with the presence of deep CMBs. Only white matter hyperintensities were independently associated with the presence of infratentorial CMBs. Compared to patients without risk factors, the frequency of deep CMBs was greater in those with a history of cerebral ischemic events (p = 0.013), while the amount of deep CMBs was higher in those with hypertension (p = 0.035).
Conclusion:
CMBs in PD seem to present a lobe-dominant pattern. A history of cerebral ischemic events and hypertension may be two strong risk factors which preferentially influences the pattern of deep CMBs in PD.
Insights
Cerebral microbleeds (CMBs) in Parkinson's disease (PD) are often lobar. A history of stroke and hypertension are key risk factors influencing deep CMBs in PD patients.
Area of Science:
- Neurology
- Radiology
- Neuroimaging
Background:
- Cerebral microbleeds (CMBs) are increasingly recognized in Parkinson's disease (PD).
- Understanding the risk factors and patterns of CMBs in PD is crucial for patient management.
Purpose of the Study:
- To investigate the risk factors associated with CMBs in PD patients.
- To analyze the pattern of CMBs in different brain locations.
- To determine how risk factors influence the pattern of CMBs in PD.
Main Methods:
- Retrospective analysis of brain susceptibility-weighted imaging data from 247 PD patients.
- Logistic regression to identify risk factors for CMBs.
- Analysis of CMB frequency and amount in various locations based on risk factors.
Main Results:
- 15.79% of PD patients had CMBs, predominantly lobar, deep, and infratentorial.
- History of cerebral ischemic events was a significant risk factor for CMBs, particularly lobar and deep.
- Hypertension and Hoehn and Yahr score correlated with deep CMBs; white matter hyperintensities with infratentorial CMBs.
Conclusions:
- CMBs in Parkinson's disease exhibit a lobe-dominant pattern.
- History of cerebral ischemic events and hypertension are significant risk factors influencing deep CMB patterns in PD.
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