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Related Experiment Video

Updated: Mar 9, 2026

Single Synapse Indicators of Glutamate Release and Uptake in Acute Brain Slices from Normal and Huntington Mice

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Deficits in temporal processing correlate with clinical progression in Huntington's disease.

P V Agostino¹, E M Gatto², M Cesarini²

¹Department of Science and Technology, National University of Quilmes/CONICET, Bernal, Buenos Aires, Argentina.

Acta Neurologica Scandinavica

|January 5, 2017

Summary

Huntington's disease (HD) patients show impaired interval timing, underestimating time and exhibiting reduced precision. This cognitive deficit correlates with clinical deterioration, suggesting timing tasks may track disease progression.

Keywords:

Huntington's disease dopamine medium spiny neurons timing and time perception

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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Area of Science:

Neuroscience
Cognitive Psychology
Neurology

Background:

Precise temporal performance is vital for complex tasks.
Interval timing (seconds to minutes) involves basal ganglia, prefrontal cortex, and dopaminergic-glutamatergic pathways.
Huntington's disease (HD) is associated with cognitive and motor deficits impacting temporal processing.

Purpose of the Study:

To assess temporal cognition in HD patients using a peak-interval (PI) time production task.
To investigate the correlation between temporal performance and the Unified Huntington's Disease Rating Scale (UHDRS).

Main Methods:

HD patients and matched controls (n=18/group) performed a PI task.
Evaluated interval timing for short (3s), medium (6s), and long (12s) durations.
Correlated timing performance with UHDRS scores.

Main Results:

HD patients demonstrated significantly worse performance on the PI task compared to controls.
HD patients underestimated time for 6s and 12s intervals and showed decreased temporal precision across all durations.
A significant correlation was found between timing performance and UHDRS scores (P<.01).

Conclusions:

Timing functions are impaired in HD and correlate with clinical deterioration.
Cognitive timing performance may serve as a valuable tool for monitoring neurodegenerative progression in HD.
Findings highlight the impact of HD on temporal processing and its clinical relevance.