Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Viruses with RNA Genomes

Viruses with RNA Genomes

RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...

Curing Methods

Curing Methods

Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...

Retroviruses

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...

Hepatic Drug Excretion: Enterohepatic Cycling

Hepatic Drug Excretion: Enterohepatic Cycling

Enterohepatic cycling involves the active secretion of drugs and their metabolites into the bile via transporters in the canalicular membrane of hepatocytes. This secretion is an integral part of the digestive process, releasing these substances into the gastrointestinal (GI) tract.
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stereoselective synthesis of 1'-α-cyano carbocyclic pyrimidine nucleoside analogs <i>via</i> a chelation-controlled 1'-α-hydroxymethylation strategy.

Organic & biomolecular chemistry·2026

Same author

Poldip2 deficiency attenuates lung disease severity in a mouse model of COVID-19.

PloS one·2026

Same author

Catching our breath: development of interventions and therapies for respiratory syncytial virus.

Microbiology and molecular biology reviews : MMBR·2026

Same author

Phospholipid-driven conformational switching of HCV NS5A links protein folding to replication membrane remodeling.

Science advances·2026

Same author

DNA-dependent RNA polymerase incorporates β-D-N4-hydroxycytidine (NHC) linking Molnupiravir to host transcription-dependent mutagenesis.

The Journal of biological chemistry·2026

Same author

Development of a melt-cast microneedle patch for sustained drug release of islatravir.

Journal of pharmaceutical sciences·2026

Search research articles

Related Experiment Video

Updated: Mar 9, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

From HCV To HBV Cure.

Raymond F Schinazi¹, Tarik Asselah²

¹Frances Winship Walters Professor of Pediatrics, Center for AIDS Research, Emory University School of Medicine, Atlanta, GA, USA.

Liver International : Official Journal of the International Association for the Study of the Liver

|January 5, 2017

Summary

This summary is machine-generated.

Direct-acting antivirals offer a cure for Hepatitis C virus (HCV) infection within weeks. This breakthrough inspires efforts to achieve a similar cure for Hepatitis B virus (HBV), aiming for global elimination of viral hepatitis.

Keywords:

HBV cure HCV elimination capsid inhibitors cccDNA direct-acting antivirals

More Related Videos

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Related Experiment Videos

Last Updated: Mar 9, 2026

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

Published on: May 10, 2022

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

"Liver-on-a-Chip" Cultures of Primary Hepatocytes and Kupffer Cells for Hepatitis B Virus Infection

Published on: February 19, 2019

Area of Science:

Hepatology
Virology
Oncology

Background:

Chronic viral hepatitis, primarily Hepatitis C virus (HCV) and Hepatitis B virus (HBV), affects millions globally.
Hepatocellular carcinoma (HCC) is a major complication, particularly in Africa, the Middle East, and Asia.
Viral hepatitis causes over one million deaths annually worldwide.

Purpose of the Study:

To review the key advancements in achieving a cure for HCV.
To discuss strategies for the global elimination of HCV.
To explore how the HCV treatment revolution can inform HBV research for a functional or sterilizing cure.

Main Methods:

Literature review of HCV direct-acting antiviral (DAA) development.
Analysis of current HBV research and development programs.
Comparative study of HCV cure strategies and their applicability to HBV.

Main Results:

Direct-acting antivirals have revolutionized HCV treatment, achieving high cure rates in 6-12 weeks.
HCV cure offers a theoretical pathway to global HCV elimination.
Significant progress in understanding viral hepatitis pathogenesis and treatment.

Conclusions:

The success of HCV treatment provides a strong model for HBV cure development.
Achieving a functional or sterilizing cure for HBV is a critical next step.
Global collaboration and research are essential for viral hepatitis elimination.