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Related Concept Videos

Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Abnormal Proliferation02:23

Abnormal Proliferation

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

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Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
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Related Experiment Video

Updated: Mar 9, 2026

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
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Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

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Myeloid-Derived Suppressor Cells.

Dmitry I Gabrilovich1

  • 1The Wistar Institute, Philadelphia, Pennsylvania. dgabrilovich@wistar.org.

Cancer Immunology Research
|January 6, 2017
PubMed
Summary

Myeloid-derived suppressor cells (MDSC) are crucial in cancer progression, promoting immune suppression, angiogenesis, and metastasis. Targeting these tumor-promoting myeloid cells offers a promising therapeutic strategy for cancer immunotherapy.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Myeloid cells are essential for host defense and tissue repair.
  • In cancer, myeloid cells are co-opted by tumors, exemplified by myeloid-derived suppressor cells (MDSC).
  • MDSCs are absent in healthy individuals but emerge in cancer and chronic inflammatory conditions.

Purpose of the Study:

  • To review the role of MDSCs in cancer progression.
  • To highlight MDSC involvement in immune suppression, angiogenesis, drug resistance, and metastasis.
  • To explore the therapeutic potential of targeting MDSCs in cancer treatment.

Main Methods:

  • Literature review and synthesis of existing research on MDSCs in cancer.
  • Analysis of MDSC biology, function, and clinical implications.

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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells
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Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

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Last Updated: Mar 9, 2026

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
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Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

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Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
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  • Evaluation of MDSCs' impact on cancer immunotherapy efficacy.

    • Main Results:

    • MDSCs are key drivers of tumor progression and immune evasion.
    • MDSCs significantly contribute to tumor angiogenesis, metastasis, and resistance to therapies.
    • MDSCs impair the effectiveness of cancer immunotherapies.

    Conclusions:

    • MDSCs represent a significant barrier to effective cancer treatment.
    • Targeting MDSCs presents a potential therapeutic avenue to enhance cancer immunotherapy and overcome resistance.
    • Understanding MDSC biology is critical for developing novel cancer treatment strategies.