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Updated: Mar 9, 2026

Analyzing and Building Nucleic Acid Structures with 3DNA

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

The 24th annual Nucleic Acids Research database issue: a look back and upcoming changes.

Michael Y Galperin¹, Xosé M Fernández-Suárez², Daniel J Rigden³

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA nardatabase@gmail.com.

Nucleic Acids Research

|January 6, 2017

Summary

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This year's Nucleic Acids Research Database Issue features 54 new and 98 updated molecular biology databases. Breakthrough resources focus on human health, including gene variants, disease phenotypes, and drug target identification.

Area of Science:

Molecular Biology
Bioinformatics
Genomics
Human Health

Background:

The Nucleic Acids Research (NAR) Database Issue presents 152 papers detailing 54 novel and 98 updated databases.
These resources cover diverse molecular biology areas such as genome structure, gene expression, and protein interactions.

Discussion:

A growing number of databases address human health, including cancer mutations, drug discovery, and therapeutic targets.
Three highlighted 'breakthrough' databases—denovo-db, Monarch Initiative, and Open Targets—focus on human de novo gene variants, disease phenotypes, and drug target validation.

Key Insights:

The issue emphasizes the increasing relevance of biological databases for human health research.
Databases like denovo-db, Monarch Initiative, and Open Targets represent significant advancements in understanding genetic variations and disease.

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Outlook:

These databases are expected to be invaluable tools for researchers in genetics and genomics.
The NAR Molecular Biology Database Collection provides a continuously updated, comprehensive resource for the scientific community.