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Immune resolution mechanisms in inflammatory arthritis
Mauro Perretti1, Dianne Cooper1, Jesmond Dalli1,2
1The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.
Nature Reviews. Rheumatology
|January 6, 2017
Summary
New strategies for inflammatory arthritis focus on resolving inflammation to promote healing. This approach aims to improve patient outcomes beyond current treatments that have limitations.
Area of Science:
- Rheumatology
- Immunology
- Drug Discovery
Background:
- Significant advancements in inflammatory arthritis treatment over the past 20 years have improved patient outcomes.
- Current therapies are not a complete solution due to non-response rates, adverse effects, and immune responses to treatments.
- Existing treatments control inflammation but lack mechanisms for tissue recovery and repair.
Purpose of the Study:
- To explore harnessing the resolution of inflammation as a novel therapeutic strategy for inflammatory diseases.
- To address the unmet need for treatments that not only control but also reverse the course of inflammatory rheumatic diseases.
Main Methods:
- This study reviews current literature on inflammatory arthritis treatments and the mechanisms of inflammation resolution.
- It analyzes the potential of targeting resolution pathways for therapeutic benefit.
Main Results:
- Current treatments for inflammatory arthritis show limitations in efficacy and safety.
- The resolution of inflammation offers a promising new avenue for therapeutic intervention.
Conclusions:
- Targeting the resolution of inflammation presents a novel approach to treating inflammatory pathologies.
- This strategy has the potential to provide a more comprehensive solution for inflammatory rheumatic diseases, promoting healing and repair.
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