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Adropin- A Novel Biomarker of Heart Disease: A Systematic Review Article
Somaye Yosaee1, Sepideh Soltani2, Eghbal Sekhavati3
1Dept. of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran; Ewaz School of Health, Larestan School of Medical Sciences, Larestan, Iran.
Insights
Low levels of the protein adropin are linked to heart disease. This review explores adropin as a potential biomarker for early heart disease diagnosis.
Area of Science:
- Cardiovascular Research
- Endocrinology
- Biomarker Discovery
Background:
- Heart disease is a leading global cause of death.
- Adropin plays a role in energy balance and insulin sensitivity.
- Endothelial dysfunction is an early indicator of heart disease.
Approach:
- Systematic review of human studies.
- Searched major scientific databases (PubMed, Scopus, Web of Science, Embase, Google Scholar, MEDLINE) up to 2015.
- Focused on studies investigating plasma adropin levels in heart disease patients.
Key Points:
- Included heart failure, coronary atherosclerosis, acute myocardial infarction, and Cardiac Syndrome X.
- Low plasma adropin levels are associated with an increased risk of heart disease.
- Adropin levels correlated with heart failure severity.
Conclusions:
- Adropin shows promise as a serum biomarker for early heart disease detection.
- Further research is warranted to validate adropin's diagnostic potential.
Background:
Heart disease is one of the most common chronic disease and leading cause of morbidity and mortality worldwide. Adropin, a newly identified protein, is important for energy homeostasis and maintaining insulin sensitivity, and has been referred to as a novel regulator of endothelial cells. Endothelial dysfunction is a key early event in atherogenesis and onset of HD. Therefore, this review gives a systematic overview of studies investigating plasma adropin level in patient with heart disease.
Methods:
Data carried out in PubMed, Scopus, Web of Science, Embase, Google scholar and MEDLINE, from the earliest available online indexing year through 2015. The search restricted to studies conducted in humans. The keyword search was adropin to apply in title, abstract and keywords. References lists of all original published articles were scanned to find additional eligible studies.
Results:
Heart failure (HF), coronary atherosclerosis acute myocardial infarction and Cardiac Syndrome X (CSX) were type of heart disease acknowledged in this study. Majority of evidences introduced low adropin as an independent risk factor of heart disease. In a case-control study, the plasma level of adropin increased with the severity of HF.
Conclusion:
Adropinmay be a potential serum biomarker for early diagnosis of HD.
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