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Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide
Published on: January 30, 2026
658
Noninvasive ventilation during the weaning process in chronically critically ill patients.
Jesus Sancho1, Emilio Servera2, Luis Jara-Palomares3
1Respiratory Care Unit, Respiratory Medicine Dept, Hospital Clínico Universitario, Valencia, Spain; INCLIVA Institute of Health Research, Valencia, Spain.
ERJ Open Research
|January 6, 2017
Summary
Noninvasive ventilation (NIV) aids weaning in chronically critically ill patients. High arterial carbon dioxide levels upon admission predict the need for NIV during the weaning process.
Area of Science:
- Critical Care Medicine
- Pulmonology
- Respiratory Therapy
Background:
- Prolonged mechanical ventilation is common in chronically critically ill patients.
- The utility of noninvasive ventilation (NIV) in weaning these patients is not well-established.
Purpose of the Study:
- To evaluate the effectiveness of NIV in weaning chronically critically ill patients.
- To identify predictors for the requirement of NIV during the weaning process.
Main Methods:
- A prospective study was conducted in Spanish respiratory care units.
- Patients underwent progressive spontaneous breathing trials, with transfer to NIV if trials could not exceed 18 hours.
- 231 chronically critically ill patients were enrolled.
Main Results:
- Weaning success was achieved in 198 patients (85.71%), with a mean weaning time of 25.45 days.
- 40 patients (21.4%) required NIV during weaning.
- Arterial carbon dioxide tension at respiratory care unit admission predicted the need for NIV (OR 1.08, p=0.013), with a cutoff of 45.5 mmHg.
Conclusions:
- Noninvasive ventilation is a valuable tool for weaning chronically critically ill patients.
- Admission hypercapnia in the respiratory care unit is a key predictor for requiring NIV during weaning.
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