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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Related Experiment Video

Updated: Mar 9, 2026

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[Chronic subdural hematoma in the elderly].

T A Juratli1, J Klein2, G Schackert2

  • 1Klinik und Poliklinik für Neurochirurgie, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland. tareq.juratli@uniklinikum-dresden.de.

Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|January 6, 2017
PubMed
Summary

Chronic subdural hematoma (cSDH) is a common condition, often requiring surgery. While surgical outcomes are generally good, even in older adults, further research is needed on potential pharmacological treatments.

Keywords:
AnticoagulantsBleedingCraniotomyGeriatricsTrepanation

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Area of Science:

  • Neurosurgery
  • Geriatric Medicine

Background:

  • Chronic subdural hematoma (cSDH) is increasingly prevalent due to aging populations and antithrombotic drug use.
  • cSDH presents with non-specific symptoms and neurological deficits, typically necessitating surgical intervention.

Purpose of the Study:

  • To review the current management and outcomes of chronic subdural hematoma.
  • To highlight the need for further investigation into adjunctive pharmacological therapies for cSDH.

Main Methods:

  • Review of current surgical standards for cSDH, including burr hole trepanation and twist drill craniostomy.
  • Discussion of recurrence rates and outcomes in elderly patients with cSDH and comorbidities.

Main Results:

  • Surgical treatment, primarily minimally invasive procedures, is the standard for cSDH.
  • Recurrences are common but often manageable, with good outcomes achievable even in elderly patients.
  • cSDH is associated with increased morbidity and mortality, particularly in patients with comorbidities.

Conclusions:

  • Current surgical approaches for cSDH are effective, with good outcomes in most cases, including the elderly.
  • Further controlled trials are required to evaluate the efficacy of pharmacological therapies as an adjunct to surgery for cSDH.