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Posterior reversible encephalopathy syndrome.

Marlene Fischer1, Erich Schmutzhard2

  • 1Department of Anesthesiology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. mar.fischer@uke.de.

Journal of Neurology
|January 6, 2017
PubMed
Summary
This summary is machine-generated.

Posterior reversible encephalopathy syndrome (PRES) is a neurological condition causing symptoms like seizures and vision loss, often linked to high blood pressure. Most patients fully recover, but some may have lasting neurological issues.

Keywords:
ChemotherapyEncephalopathyHypertensive encephalopathyPreeclampsiaVasogenic edema

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Area of Science:

  • Neurology
  • Radiology

Background:

  • Posterior reversible encephalopathy syndrome (PRES) is a neurological disorder with acute onset.
  • Clinical presentation includes headache, visual deficits, confusion, seizures, and focal neurological deficits.
  • Elevated arterial blood pressure is common in PRES patients.

Purpose of the Study:

  • To describe the clinical presentation, neuroimaging findings, associated conditions, treatment, and prognosis of PRES.

Main Methods:

  • Review of clinical data and neuroimaging findings (MRI) in patients with PRES.
  • Analysis of underlying conditions contributing to PRES development.
  • Evaluation of treatment strategies and patient outcomes.

Main Results:

  • PRES is characterized by a distinct parieto-occipital pattern of vasogenic edema on MRI.
  • Commonly associated with cytotoxic medication, (pre)eclampsia, sepsis, renal disease, or autoimmune disorders.
  • Most patients experience reversible clinical symptoms and imaging lesions.

Conclusions:

  • PRES is a reversible neurological condition with a generally favorable prognosis.
  • Treatment is symptomatic and guided by the underlying cause.
  • Neurological sequelae, such as epilepsy, can persist in some individuals.