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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

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Published on: April 14, 2014

Pupil cycle time: as indicator of visual pathway dysfunction in multiple sclerosis.

Eyyup Karahan¹, Omer Karti², Aslı Koskderelioglu³

¹Department of Ophthalmology, Van Training and Research Hospital, Van, Turkey.

Acta Neurologica Belgica

|January 6, 2017

Summary

Pupil cycle time (PCT) effectively indicates optic nerve dysfunction in multiple sclerosis (MS) patients. This non-invasive measure correlates with MS duration and visual pathway integrity, offering a potential tool for assessing optic nerve health.

Keywords:

Multiple sclerosis Optical coherence tomography Pupil cycle time Visual evoked potential

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Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats

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Published on: January 10, 2019

Area of Science:

Ophthalmology
Neuroscience
Clinical Research

Background:

Multiple sclerosis (MS) frequently causes optic nerve dysfunction.
Current methods for assessing optic nerve health in MS can be invasive or limited.
Pupil cycle time (PCT) is a potential, non-invasive indicator of neurological function.

Purpose of the Study:

To investigate the utility of pupil cycle time (PCT) as a biomarker for optic nerve dysfunction in patients with multiple sclerosis (MS).
To compare PCT in MS patients with and without a history of optic neuritis (ON) against healthy controls.
To explore correlations between PCT and various clinical and imaging parameters related to MS and optic nerve health.

Main Methods:

A study cohort included 42 MS patients (divided into ON history and no ON history groups) and 35 healthy controls.
Statistical analyses included Chi-square and one-way ANOVA tests for group comparisons.
Correlational analyses examined relationships between PCT and age, visual acuity, MS duration, visual field (VF) tests, visual evoked potential (VEP) latencies, and retinal nerve fiber layer (RNFL) and ganglion cell layer-inner plexiform layer (GCL-IPL) thicknesses.

Main Results:

Mean PCT was significantly higher in MS patients compared to controls (Group 1: 1286.4 ± 357.8 ms; Group 2: 1021.3 ± 102.3 ms; Group 3: 872.5 ± 69.4 ms; p < 0.001).
Moderate to significant correlations were observed between PCT and MS duration, VF test results, VEP latencies, RNFL thickness, and GCL-IPL thickness.
These findings suggest PCT is sensitive to optic nerve alterations in MS.

Conclusions:

Pupil cycle time (PCT) demonstrates significant potential as a non-invasive indicator of optic nerve dysfunction in multiple sclerosis (MS).
PCT measurements correlate with key clinical and imaging markers of MS-related visual pathway damage.
PCT may serve as a valuable alternative method for monitoring optic nerve health in MS patients.