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Published on: May 9, 2022
Comparison between two antimicrobial protocols with or without guided bone regeneration in the treatment of
Umberto Demoner Ramos1, Flavia Adelino Suaid1, Ulf M E Wikesjö2
1Department of Bucco-Maxillo-Facial Surgery and Traumatology, and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
Objectives:
This study used a dog model to evaluate two antimicrobial protocols with or without guided bone regeneration (GBR) in the surgical reconstruction of peri-implantitis defects.
Material And Methods:
Eight beagle dogs subject to ligature-induced peri-implantitis were used. The animals either received antimicrobial photodynamic therapy or topical tetracycline hydrochloride combined with GBR or as stand-alone surgical interventions. Block biopsies of the defect sites for histological analysis were obtained at euthanasia, 12 weeks postsurgery. The primary outcome of the study was re-osseointegration; secondary outcomes included alveolar bone gain and remaining defect characteristics. The effects of the implant site, early exposure, and type of antimicrobial protocol on bone regeneration were also evaluated.
Results:
No significant differences were observed between the two antimicrobial protocols, and the adjunctive use of GBR failed to significantly improve re-osseointegration or bone gain using either protocol. Buccal sites and implant early exposure negatively affected bone regeneration.
Conclusion:
Both antimicrobial therapies stand-alone or combined with GBR allowed similar and limited bone gain.
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