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Updated: Mar 9, 2026
Oropharyngeal Administration of Bleomycin in the Murine Model of Pulmonary Fibrosis
Published on: May 9, 2025
Combined prednisolone and pirfenidone in bleomycin-induced lung disease
Preyas J Vaidya1, H S Sandeepa2, Tejinder Singh3
1Institute of Pulmonology, Medical Research and Development; Lung Care and Sleep Center, Fortis Hospitals, Mumbai, Maharashtra, India.
Abstract:
Bleomycin is a cytostatic drug commonly employed in the treatment of Hodgkin's disease, seminomas, and choriocarcinoma. Bleomycin may induce a chronic pulmonary inflammation that may progress to fibrosis. So far, only corticosteroids have been used in the treatment of bleomycin-induced lung disease with variable results. Pirfenidone is an antifibrotic drug that has been approved for the treatment of idiopathic pulmonary fibrosis. We report two cases of bleomycin-induced lung disease treated successfully with pirfenidone and oral corticosteroids.
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