Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thin membrane nephropathy: a clinico-pathological study.

I Aarons1, P S Smith, R A Davies

  • 1Institute of Medical and Veterinary Science, Adelaide, South Australia.

Clinical Nephrology
|October 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of a novel viral filter on cardiopulmonary exercise testing during the COVID-19 pandemic.

Anaesthesia·2021
Same author

A survey of current management of Benign Paroxysmal Positional Vertigo (BPPV) by physiotherapists' interested in vestibular rehabilitation in the UK.

Physiotherapy·2018
Same author

Blazar spectral variability as explained by a twisted inhomogeneous jet.

Nature·2017
Same author

Audiometry and other hearing tests.

Handbook of clinical neurology·2016
Same author

Communication about safer sex and serostatus disclosure in HIV-positive adolescents with haemophilia.

Haemophilia : the official journal of the World Federation of Hemophilia·2016
Same author

Hemophagocytic syndrome complicating cardiac transplantation.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same journal

Clinical characteristics and outcomes of adults with minimal change disease: A retrospective, cross-sectional study.

Clinical nephrology·2026
Same journal

Analysis of end-stage renal disease mediated by cuproptosis-related genes.

Clinical nephrology·2026
Same journal

The relationship between red cell distribution width and platelet ratio in acute kidney injury among ventilator-associated pneumonia patients: A MIMIC-IV database study.

Clinical nephrology·2026
Same journal

Arterial stiffness and choroidal vascularity index in autosomal dominant polycystic kidney disease with preserved kidney function.

Clinical nephrology·2026
Same journal

Antibody-drug conjugate therapy in a renal transplant patient with bladder cancer: A case report.

Clinical nephrology·2026
Same journal

Epigenetic age enhances eGFR-based prediction of all-cause mortality: A cross-cohort validation of a novel risk model.

Clinical nephrology·2026
See all related articles

Thin membrane nephropathy, a common kidney disease found in 11% of renal biopsies, often has a family history. Diagnosis relies on electron microscopy, with mild light microscopy changes predicting ultrastructural findings.

Area of Science:

  • Nephrology
  • Pathology
  • Genetics

Background:

  • Thin membrane nephropathy (TMN) is a frequent finding in non-transplant renal biopsies, accounting for approximately 11%.
  • A significant familial predisposition is noted, with at least 40% of patients reporting a family history of renal disease.
  • TMN diagnosis is critically dependent on electron microscopy.

Purpose of the Study:

  • To elucidate the diagnostic criteria and clinical implications of thin membrane nephropathy.
  • To investigate the relationship between morphological changes, clinical presentation, and familial history in TMN.
  • To explore the ultrastructural basis of TMN and its potential impact on renal function.

Main Methods:

  • Analysis of non-transplant renal biopsies with a focus on light and electron microscopy.

Related Experiment Videos

  • Immunofluorescence and immunogold studies to assess basement membrane composition.
  • Correlation of morphological findings with clinical data and family history.

    • Main Results:

    • Light microscopy shows usually mild changes that predict ultrastructural findings, but without correlation to their severity.
    • Electron microscopy is essential for diagnosis, revealing reduction or loss of the subepithelial basement membrane.
    • No clear correlation exists between the extent of morphological changes and clinical or familial features.
    • The subepithelial basement membrane appears to contain normal amounts of type IV collagen despite reduction or loss.

    Conclusions:

    • Awareness of thin membrane nephropathy can help avoid unnecessary urological investigations.
    • Microscopic examination of urine for dysmorphic red blood cells is a valuable diagnostic clue.
    • Prospective long-term studies are required to fully understand the nature and consequences of TMN.