Related Experiment Video
Updated: Mar 9, 2026
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Urine Output during Cardiopulmonary Bypass Predicts Acute Kidney Injury after Coronary Artery Bypass Grafting
Mehmet Yilmaz1, Rezan Aksoy2, Vildan Kilic Yilmaz3
1Department of Anesthesiology and Reanimation, Derince Research and Education Hospital Kocaeli, Turkey.
Insights
Low urine output during cardiopulmonary bypass may predict acute kidney injury after coronary artery bypass grafting. Monitoring urinary output can help maintain kidney function post-surgery.
Area of Science:
- Nephrology
- Cardiovascular Surgery
Background:
- Acute kidney injury (AKI) is a common complication after coronary artery bypass grafting (CABG).
- Predictive markers for AKI in the perioperative period are crucial for patient management.
Purpose of the Study:
- To evaluate the association between intraoperative urinary output during cardiopulmonary bypass (CPB) and the development of postoperative AKI in CABG patients.
- To determine if urinary output during CPB can serve as a predictive factor for AKI.
Main Methods:
- Retrospective analysis of 200 patients undergoing isolated CABG between 2012-2014 with normal preoperative creatinine.
- Patients were categorized based on the presence or absence of AKI on postoperative day 3, using RIFLE criteria.
- Comparison of intraoperative urinary output (mL/kg/hour) between AKI and non-AKI groups.
Main Results:
- Patients who developed AKI had significantly lower urinary output during CPB compared to those without AKI (P = .022).
- A urinary output threshold of 3.70 mL/kg/hour or lower demonstrated 71.43% sensitivity in predicting AKI positivity.
- Intraoperative urinary output emerged as a significant predictor of postoperative AKI.
Conclusions:
- Urinary output during CPB is a valuable indicator for predicting AKI following CABG.
- Strategies aimed at increasing intraoperative urinary output may help preserve renal function during and after cardiac surgery.
Objective:
This study evaluated the relationship between the amount of urinary output during cardiopulmonary bypass and acute kidney injury in the postoperative period of coronary artery bypass grafting.
Methods:
Two hundred patients with normal preoperative serum creatinine levels, operated on with isolated CABG between 2012-2014 were investigated retrospectively. The RIFLE (Risk, injury, failure, loss of function, and end-stage renal disease) risk scores were calculated for each patient in the third postoperative day. Patients were distributed into two groups in relation to the presence of acute kidney injury or not and these two groups were compared.
Results:
The urinary output (mL/kg/hour) during cardiopulmonary bypass in the acute kidney injury negative group was significantly higher than in the acute kidney injury positive group (P = .022). In case of a urinary output value 3.70 and lower to predict acute kidney injury positivity, sensitivity was detected as 71.43%. Results of the analysis for urinary output predict positivity of acute kidney injury.
Conclusion:
We suggest that urine output during cardiopulmonary bypass is a significant criteria that could predict acute kidney injury following coronary artery bypass grafting with cardiopulmonary bypass. Attempts to increase the urine output during cardiopulmonary bypass could help to maintain the renal functions during and after surgery.
Related Concept Videos
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
01:22Acute Kidney Injury I: Introduction
01:29Acute Kidney Injury II: Pathophysiology
01:20Acute Kidney Injury V: Interprofessional Care
01:26Kidney Transplant II: Surgical Procedure
01:29Acute Kidney Injury III: Clinical Manifestations