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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

Bai Ji1,2, Benjamin R E Harris3, Yahui Liu4

  • 1Department of Hepatobiliary and Pancreatic Surgery, the First Hospital of Jilin University, Changchun 130021, China. bji@hi.umn.edu.

International Journal of Molecular Sciences
|January 6, 2017
PubMed

Insights

This review explores how internal ribosome entry site (IRES) elements control p53 translation after DNA damage. Understanding these mechanisms may reveal new cancer diagnostics and treatments.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • Translational regulation of p53 via its 5'-untranslated region internal ribosome entry site (IRES) after DNA damage is established.
  • The precise mechanisms governing p53 IRES-mediated translation remain largely unelucidated.

Purpose of the Study:

  • To review recent advancements in identifying novel regulatory proteins of the p53 IRES.
  • To explore the link between impaired IRES-driven p53 translation and tumor development.
  • To discuss implications for understanding oncogenesis and developing cancer therapeutics.

Main Methods:

  • Literature review of recent studies on p53 IRES function.
  • Analysis of regulatory proteins interacting with the p53 IRES.
  • Examination of the connection between IRES defects and tumorigenesis.

Main Results:

  • Identification of novel proteins that regulate p53 IRES activity.
  • Evidence linking aberrant IRES-mediated p53 translation to increased cancer risk.
  • Potential biomarkers and therapeutic targets emerging from IRES research.

Conclusions:

  • Further research into p53 IRES regulation is crucial for understanding cancer.
  • Defective IRES function in p53 translation is implicated in oncogenesis.
  • Findings offer new strategies for cancer diagnosis and treatment.
Keywords:
DNA damageIRES-trans acting factors (ITAFs)internal ribosome entry site (IRES)p53

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