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Hepatic Lipodystrophy in Galloway Calves.

M Wieland1,2, S Mann1,2, A Hafner-Marx3

  • 11 Clinic for Ruminants with Ambulatory and Herd Health Services at the Centre for Clinical Veterinary Medicine, LMU Munich, Oberschleissheim, Germany.

Veterinary Pathology
|January 6, 2017
PubMed
Summary
This summary is machine-generated.

Hepatic lipodystrophy in Galloway calves is a fatal liver disease. This study details clinical and pathological findings in German calves, aiding diagnosis of this rare condition.

Keywords:
cattleglutathione peroxidasehepatic diseasehepatic encephalopathyhepatic fibrosishepatic lipidosishepatic lipodystrophy

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Area of Science:

  • Veterinary Pathology
  • Animal Science
  • Hepatology

Background:

  • Hepatic lipodystrophy is a fatal liver disease in Galloway calves.
  • The condition affects a small proportion of the breed in Europe and North America.
  • Its etiopathogenesis remains largely unknown, with infectious, toxic, or hereditary causes considered.

Purpose of the Study:

  • To describe hepatic lipodystrophy in Galloway calves from a German cow-calf operation.
  • To document clinical, clinical pathology, and postmortem findings.
  • To provide diagnostic insights for this rare liver disorder.

Main Methods:

  • Clinical examination of affected calves.
  • Clinical pathology analysis including bilirubin and enzyme levels.
  • Postmortem examination and histological assessment of liver tissues.

Main Results:

  • Clinical signs consistent with hepatic encephalopathy were observed.
  • Elevated total and direct bilirubin, GGT, and GLDH activities were noted.
  • Decreased glutathione peroxidase activity and characteristic liver lesions (fibrosis, lipidosis, bile duct hyperplasia) were found.

Conclusions:

  • The findings align with previous descriptions of hepatic lipodystrophy in Galloway calves.
  • The study contributes to understanding the clinical and pathological presentation of the disease.
  • A diagnostic protocol is outlined to assist in identifying this condition.